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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AB3P
All Species:
22.12
Human Site:
S333
Identified Species:
40.56
UniProt:
Q58FF7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q58FF7
NP_031381
597
68325
S333
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
S469
E
L
L
R
Y
Y
T
S
A
S
G
D
E
M
V
Rhesus Macaque
Macaca mulatta
XP_001098219
597
68451
S333
E
D
L
P
L
N
I
S
R
E
M
L
Q
Q
S
Dog
Lupus familis
XP_532154
636
72879
E372
S
C
D
E
L
I
P
E
Y
L
N
F
I
R
G
Cat
Felis silvestris
Mouse
Mus musculus
P11499
724
83307
S460
E
L
L
R
Y
H
T
S
Q
S
G
D
E
M
T
Rat
Rattus norvegicus
P34058
724
83263
S460
E
L
L
R
Y
H
T
S
Q
S
G
D
E
M
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518700
789
90657
S552
E
L
L
R
Y
H
T
S
Q
S
G
D
E
M
T
Chicken
Gallus gallus
Q04619
725
83409
S461
E
L
L
R
Y
H
T
S
Q
S
G
D
E
M
T
Frog
Xenopus laevis
NP_001086624
722
82939
S458
E
L
L
R
Y
H
T
S
Q
T
G
D
E
M
A
Zebra Danio
Brachydanio rerio
Q90474
725
83300
S461
D
L
L
R
Y
Y
T
S
A
S
G
D
E
M
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
S453
D
F
L
R
F
H
T
S
A
S
G
D
D
F
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
T438
S
D
F
L
R
Y
S
T
S
A
G
D
E
P
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P55737
699
80046
T439
E
L
L
R
Y
H
S
T
K
S
G
D
E
L
T
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69
95.8
83.6
N.A.
78.4
78.8
N.A.
67.5
74.7
73.5
66.3
N.A.
64
N.A.
61.9
N.A.
Protein Similarity:
100
76.2
97.8
86
N.A.
80.3
80.6
N.A.
70.3
79
78.3
75.3
N.A.
73.2
N.A.
73.5
N.A.
P-Site Identity:
100
20
100
6.6
N.A.
20
20
N.A.
20
20
20
13.3
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
26.6
100
13.3
N.A.
46.6
46.6
N.A.
46.6
46.6
46.6
26.6
N.A.
26.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
57
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
71.1
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
24
8
0
0
0
0
8
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
16
24
8
0
0
0
0
0
0
0
0
77
8
0
0
% D
% Glu:
70
0
0
8
0
0
0
8
0
16
0
0
70
0
0
% E
% Phe:
0
8
8
0
8
0
0
0
0
0
0
8
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
77
0
0
0
8
% G
% His:
0
0
0
0
0
54
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
16
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
62
85
8
24
0
0
0
0
8
0
16
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
16
0
0
54
0
% M
% Asn:
0
0
0
0
0
16
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
16
0
0
8
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
39
0
0
0
16
16
0
% Q
% Arg:
0
0
0
70
8
0
0
0
16
0
0
0
0
8
0
% R
% Ser:
16
0
0
0
0
0
16
77
8
62
0
0
0
0
16
% S
% Thr:
0
0
0
0
0
0
62
16
0
8
0
0
0
0
47
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
62
24
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _